Top 10 Challenges for Bioinformatics
- Precise models of where and when transcription will occur in a genome (initiation and termination).
- Precise, predictive models of alternative RNA splicing.
- Precise models of signal transduction pathways; ability to predict cellular responses to external stimuli.
- Determining protein: DNA, protein: RNA, protein: protein recognition codes.
- Accurate ab initio protein structure prediction.
- Rational design of small molecule inhibitors of proteins.
- Mechanistic understanding of protein evolution.
- Mechanistic understanding of speciation.
- Development of effective gene ontologies: systematic ways to describe gene and protein function.
- Education: development of bioinformatics curricula.
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